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To develop metastasis in a distant organ, cancer cells must initially disseminate from the primary tumor and invade through the surrounding basement membrane and stroma into lymphatic or blood vessels, followed by survival, extravasation and re-implantation at a secondary site [ 2].
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Studies of these sediments indicate the presence of metals initially disseminated in newly erupted underwater volcanic rocks.
This paper considers two sites where western harmony was initially disseminated in the context of colonialism, drawing on fieldwork conducted in Yaoundé, the capital of Cameroon, and the city of Winnipeg in western Canada.
We collected 5312 questionnaires out of 7704 that were initially disseminated, representing a response rate of 68.95%.
Less than 0.00004% of initially disseminated cells complete the metastatic process, and yet, it is these few cells which lead that charge of cancer mortality.
Of note, 83.3% of melanomas arising from upper gastrointestinal tract presented with initially disseminated disease, which was much higher than the rate of metastatic disease in all cases (16.3%).
Neisseria gonorrhoeae strains with resistance to extended-spectrum cephalosporins (ESCs), last options for first-line monotherapy of gonorrhoea, likely emerged and initially disseminated in Japan, followed by international transmission.
These accounts initially were disseminated in an oral-poetic tradition; today the Greek myths are known primarily from Greek literature.
Initially, cancer cells disseminate to milky spots where the basement membrane is disrupted and where they have direct access to the collagen I-rich connective tissue matrix.
The view of "Art-for-Art's Sake," or sometimes stated as "l'art pur," initially broadcast by Constant and Madame De Stael was disseminated in Paris where it influenced people like the philosophy professor, Victor Cousin, and the writer Theophile Gautier who spread the doctrine even more widely.
Based on the principles of enzymatic nucleic acid labeling and DNA hybridization, the basic techniques were initially developed and disseminated by Patrick Brown's laboratory at Stanford and by others using "open source" approaches to techniques and instrumentation.
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