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It is of note that pyrazole structures have initially been recognized as effective inhibitors of NFAT signalling via an ill-defined mechanism downstream of Ca2+ signalling (Djuric et al., 2000; Trevillyan et al., 2001).
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Anxiety is common in cancer patient populations, and must often initially be recognized and managed by cancer care professionals.
This can initially be recognized as a rounding of the basal pole of the crypt cells, which precedes the rounding of the completely isolated cell (15).
Newly created alternative MDSs, that arise from either MDS duplication or incorporation of noncoding sequences, might initially be recognized erroneously by the long template RNAs (Nowacki et al. 2008) that derive from the ancestral genes with the constitutive MDSs.
Initially, monoplacophorans were recognized by the presence of multiple, symmetrical muscle scars in patelliform shells, but then multiple muscle scars were also found in high conic shells and also in coiled ones.
Initially they were recognized as natural suppressor cells located in the bone marrow and spleen that were able to suppress cell-mediated immunity [ 54].
Initially it was recognized as a syndrome in inpatient psychiatric facilities, and is now used to describe a set of maladaptive behaviours that are induced by the tensions of living in any institution [ 37, 64- 66].
Initially, p53 was recognized for its ability to respond to DNA damage by transactivating several genes that regulate cell cycle progression (e.g., CDKN1A) and apoptotic cell death (e.g., BAX), hence preventing the propagation of potentially transforming genetic defects.
The availability of efficient mapping systems to produce accurate representations of initially unknown environments is recognized as one of the main requirements for autonomous mobile robots.
Initially, Alba proteins were recognized as chromosomal proteins and supposed to be involved in the maintenance of chromatin architecture and transcription repression.
Initially the pattern was recognized with a stretch of CREMP sequence that showed a strict alternation of a- and b- type modules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com