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This form of cell-based therapy, though initially applicable in only the 25-30% of patients with histocompatible donors, was associated with success in several patients with severe immunodeficiencies, congenital bone marrow failures of several types and even the inherited hemoglobin disorders [ 14].
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Initially only applicable to small genomic sequences such as the genome of the bacteriophage λ [2] and viruses [3], [4] and bacterial artificial chromosomes (BACs), sequencing was expensive and required a great deal of manual labor in order to assemble the reads into the underlying sequence.
What Raymer initially lacks in applicable skills she makes up for with her performance on the job, and with a sheer fondness for gambling inherited from her adoptive father (who did have a problem).
For reasons to be discussed later, limitations in their mathematical framework initially made the theory applicable only under special and limited conditions.
Similarly sensitivity analysis was also performed to assess the effect of those items assessed as not applicable, with their initially exclusion to the analysis and then addition as if they were reported so as not to penalise studies which had a larger number of not applicable items and would therefore potentially have a seemingly lower compliance with STARD.
Although the tool was initially developed for ChEBI, it is applicable to any ontology.
This problem is framed initially as one that is directly applicable to a biological aim to understand the relationship between organismal structure and function.
Initially, we attempted two normalization methods applicable for both Agilent and Affymetrix array types analyzed in our studies: i) RMA background correction [ 46] followed by quantile normalization with [ 47]. and ii) normalization by ACTB gene expression values.
Thus clinical research conclusions meant immediately applicable lessons for clinical practice, although, initially, these would still be under the general oversight of the clinician.
He expects the base catalyst to be available in "small ton quantities" within about two years, adding that the technology may initially be a niche technology before it becomes applicable in large wastewater facilities.
This is partly because the molecular origin of the hydrophobic effect, initially proposed by Kauzman and Tanford, is not universally applicable, and it appears that depending on the molecular context, the hydrophobic effect is either enthalpically or entropically dominated.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com