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Table 2 represents the parameters and their ranges to initialise the model functioning.
Meteorological data used to initialise the model are normally obtained from measurements or from outputs from larger scale numerical models.
In a similar spirit to the popular motif finder MDscan [ 22], we combine a maximum likelihood approach with enumerative methods to initialise the model's parameters.
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This approach allowed us to calculate the number of connections removed by slice cutting for each neuron, and reduce its number of connections accordingly when initialising the model.
Then the boundary is initialised starting from the model and an heuristic optimisation scheme is applied to guide the search of the final form.
To evaluate Φ ( V 0 ; μ 0 ) we first lift V 0 to produce v 0, where L ( V 0 ) = v 0. We then initialise the fine-scale model (70) with the initial condition v 0 (and μ = μ 0 ) and simulate (70) for a short amount of time, of duration say Δ, resulting in the state v.
The entrance in the cell cycle S (synthesis) phase is represented through the dynamics of both the transcription factor E2F and cyclin E. In order to simulate the pathological state described in the G2SBC Database (cyclin D overexpression), it is possible to select the model and initialise it with a higher value of the cyclin D initial concentration.
The state of the model is initialised by setting an initial configuration of agent attributes.
The model was initialised with boundary conditions from the USGS PRISM2 data set and a Pliocene atmospheric CO2 level of 400 ppmv and run for 300 simulated years.
To this purpose, the model was initialised with temperature and wind speed profiles from the meteorological soundings registered at Grand Junction station, located 300 km upwind of Boulder.
The model was initialised with a single infected farm (Baylham Farm, near Ipswich) on 4 August 2007.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com