Sentence examples for initial variants from inspiring English sources
Briefly, initial variants were called independently using two algorithms to obtain a more robust SNP set, as recommended by [ 64].
Initial variants showed a significant loss in binding affinity, but further exploration of the SAR revealed that pyridines carrying a substituent at the 4-position were optimal for enzyme inhibition and this allowed the IC50 to be restored to the double-digit nanomolar range (Table 5).
Initial variants can be loaded into the system from external sources (e.g., data downloads from dbSNP or locus-specific databases or manual entry from literature curation), but every variant is assessed by the LMM and verified by a board-certified geneticist before it is incorporated into a patient's report.
For our use case with sorghum, we (i) generated an initial set of variants using reduced representation sequence data from an experimental cross and association panels, (ii) used the initial variants to inform variant calling from WGS data of resequenced individuals, and (iii) used variants identified from WGS data for recalibration of the reduced representation sequence data.
In the initial variant, called invisible graph searching, the searchers do not know the position of the fugitive until they catch it.
Given the potential for false positives identified in genome sequencing, a stringent read depth of 50 and a call quality of 100 (calculated by complete genomics and based on a phred scale) were chosen as parameters for initial variant filtering.
In 2012, Airbus announced another increase in the A380's maximum take-off weight, to 575 t, a 6t hike on the initial variant and 2t higher than the increased-weight proposal of 2010.
Two initial variant sets were designed: 21 variants of the polymerase gene and 24 of the scFv.
Initial variant calling was generated using Torrent Suite Software v4.0 using the variant caller plug-in.
After the initial variant calling, SNPs were filtered based on several criteria.
Applying these filters, the initial variant number was reduced by a factor of 10.
