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After those initial four hours, which I spent reciting the script in front of a mirror while holding a pen as if it was a microphone, I would occasionally run through it in my head, usually on a train or in bed.

Patients were evaluated for age, sex, prescription opioid use, and for the type of assisted ventilation required during the initial twenty- four hours of their stay.

As shown in Table 3 two adult studies showed paradoxical worsening of ketonemia, including a slower decline in ketonemia in the first hour of bicarbonate infusion in a RCT [13], and an increase in plasma acetoacetate levels during the initial three hours of bicarbonate infusion in a small, prospective, nonrandomized study [19].

Vertical profiles of a temperature and b water vapor content differences (E_mp2 minus N_mp2) averaged for the initial three hours, and c latent heating rate in E_mp2 (blue), E_mp4 (green), and N_mp2 (purple) averaged for the 6-day integration (the difference from E_mp2 is also plotted by thin lines), over the (120° 160°E, 10°S 20°N) domain.

Staff at the Allstars Sports Bar in Bristol, southwest England, spent an initial four hours setting up the 500-foot long stunt — and a further five hours tweaking it until, after more than 100 attempts, it succeeded.

The initial three hours of these rounds took place within the peripheral conference room.

Table 2 shows the resuscitative interventions utilized in the initial six hours of EGDT between the groups.

Thereafter, we analyzed the changes in the REM sleep amount during the initial three hours and after three hours of lansoprazole injection.

Lactate clearance for 48 hours was defined according to the following formula: lactate clearance for 48 hours  = [(highest lactate level in the initial six hours – lowest lactate level in the first 24 to 48 hours)/highest lactate level in the initial six hours] × 100.

Finally, the exceptionally high rate of transfusion (64%) during the initial six hours of therapy in the original EGDT study [ 1] has failed to be approximated in any subsequent randomized or observational study of EGDT [ 10, 31- 35, 47].

As our intent was to measure the potential impact of the early resuscitation program, subjects who did not survive the first six hours of early resuscitation (e.g. care was withdrawn early or the subject dies prior to the initial six hours of resuscitation) were excluded post-hoc from both groups.

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