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Of the 112 neonates, 53 neonates (47%) had sub-therapeutic initial trough serum concentrations of vancomycin, whereas 22% had supra-therapeutic initial trough serum concentrations.
Forty-seven percent of the neonates had sub-therapeutic initial trough serum concentrations of vancomycin.
In the present study, we studied initial trough serum concentrations of vancomycin in critically ill neonates.
In all patients doses were adjusted on basis of the initial trough concentration.
A remaining total of 112 initial trough serum concentrations were analyzed.
In the first three age categories, 3 out of 7 patients had sub-therapeutic initial trough serum concentrations, whereas 1 patient had a supra-therapeutic initial trough serum concentration.
Similar(20)
Initial troughs were read only when they preceded the primary crest.
The tsunami arrival times and the subsequent arrivals of initial troughs, primary crests, and local crests were then read manually from the processed waveform data.
The initial trough-like configuration was created about 35 million years ago as a forearc basin while the Pacific Plate subducted beneath the North American Plate.
Among the 151 patients in which an initial vancomycin trough was obtained, a lower vancomycin trough level was not associated with increased mortality in our cohort, which has been reported by others [ 22].
A first-order interaction term of initial vancomycin trough level (< or ≥ 15 μg/dL) and vancomycin MIC was created to determine if a lower vancomycin trough and higher vancomycin MIC independently increased mortality.
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