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They transplanted neural stem cells derived from eight patients with open-head injuries back into the patients who had provided the initial tissue and allowed the cells to migrate to the injury sites.
After adjusting for the initial tissue slack, the maximum strain ranged from 23.8%to30.0%0%.
Initial tissue thickness and deformation were measured using M-mode ultrasound; indentation forces were recorded simultaneously.
Linkevicius et al. showed that the initial tissue thickness influences crestal bone changes around implants [10, 11].
Stress was calculated by dividing the force by the initial tissue cross-sectional area, assuming a rectangular geometry (Table 1).
Initial tissue quality is also an issue as the majority of the cadaveric specimen is from elderly donors with osteoporosis, or other degenerative pathologies.
The initial tissue expander placement and the subsequent exchange for an implant each take about 1 h in the operating room.
That age and tissue had little mechanical effect, tentatively suggest that variations in enzymatic cross-links may play a minor role after initial tissue formation.
The pharmacokinetics examined in rodents indicates fast localization of the tracer to its intended target (favourable for rapid 11C-based imaging) and limited metabolism with high levels of intact tracer during the initial tissue accumulation phase.
Analysis of ECM alignment over time revealed that tissues rapidly reorganize their surrounding matrix, with a characteristic time that depends on the type of cell and the initial tissue geometry.
Closed circuit perfusion (Creech-Krementz), chemofiltration infusion and «stop-flow» perfusion (Aigner) and regional limb infusion (Thompson) are more complex techniques aimed at even greater localized initial tissue chemotherapy concentrations over a short time span.
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