If we take more effective control measures for infectious diseases at the initial time of the diseases' spread, then the diseases go to extinction more quickly.
From the numerical simulations, strengthening the treatment rate after the infective individuals reach some level is also effective for disease control, even though we do not take any treatment measures at the initial time of the disease's outbreak.
At that initial time of impact, few things bring comfort.
Time to disease progression (TTP), was defined as the interval between initial treatment and the time of disease progression or death.
PFS was defined as the interval between the date of the initial debulking surgery and the time of disease progression or the last date of follow up.
Note that the bad fit of the estimated relapses to the actual data, for the first years, is due to the fact that, for simplicity, the estimate used did not include the variability, among patients, given by the time of disease detection, initial tumor load and its growth rate.
For a generic subject, let Z be the survival time, defined as the time elapsed between some initial time point, where the subject is disease-free, and the development in time of disease.
The treatment groups may differ slightly at the initial time point of this analysis with respect to disease activity, concomitant medication or time in the study.
We expect that protein profiling of PCa biopsy specimens would be performed at the time of initial diagnosis of disease for prediction of the likely behavior of the cancer.
Second, the clinical spectrum of septic shock is wide and highly dynamic, and although all patients were included during the first 24 hours after ICU admission, time from initial presentation of disease to echocardiogram and other measurements varies.
