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Research investigating the underlying mechanisms of human disease, as well as the initial testing of therapeutic agents, depends heavily on animal models.
Patients who showed response to the initial drug were maintained on that therapeutic agent.
Initial trials of DFMO as a cancer therapeutic agent were disappointing, showing dose-limiting toxicity, together with little therapeutic activity.
Discontinuation of rheumatoid arthritis (RA) treatment for lack or loss of initial response, tolerability issues, or development of antibodies against the therapeutic agent remains a challenge in clinical practice.
Although corticosteroids often remain the initial therapeutic choice, side effects and limited efficacy require additional steroid-sparing agents.
Initial work with animal models highlighted the possible use of rhAPC as a therapeutic agent.
Until head-to-head trials or large-scale observational studies that reflect routine use of these agents are available, such adjusted indirect comparisons based on trial data are one tool to guide initial therapeutic choices.
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.
No other therapeutic agent "has so many demonstrated uses," he says.
Thus, cyclosporine A may be a new therapeutic agent for cardiac hypertrophy through inhibiting ERS.
Thus, INH-ODN-24888 represents a promising therapeutic agent for the treatment of SLE.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com