He argues that this initial study points to the effectiveness of the program, saying that small changes in such a large group — there were 22,000 surveyed — are important indicators.
These initial studies pointed out that they are widely occurring PTMs in both bacterial and mammalian cells.
Although initial studies pointed towards a central role of IL-10 in mediating Tr1 generation, recent studies indicate that Tr1 generation could also be dependent on IL-27.
Initial studies pointed to a model that the SIR complex silences transcription by promoting the formation of a more protected chromatin structure that is not accessible to the transcription machinery.
For studies performed with activin A stimulation, SP1, SRE, NFκB, RXR, and p53 had differential activity relative to vehicle at the initial study time point (Fig. 6).
Here, the optimized cutoff value of the STESS was ≥4 (best match for both sensitivity (0.69) and specificity (0.41)), which was different from that proposed by the initial study (≥3 points) [ 3].
Following-up to our initial study that pointed to putative susceptibility loci for risk and size of UL on chromosome 1q43, we conducted a two-stage re-sequencing and follow-up genotyping study and evaluated the predictive value of a stringent selection of 221 SNPs.
○ Time to onset of effect, defined as the time from the initial study dose to a 2-point reduction in PGA in ≥30% of subjects, a variable that was not consistent with time to response, given that this was a population-based (not subject-based) analysis.
Patients were evaluated by an investigator who had not been involved in the initial study and at just one time point during the first day of hospitalization after initial resuscitation.
Although our initial study (Tritsch et al. 2012) pointed to GABA as being the transmitter released by dopamine neurons, we acknowledged that other molecules might perform similar functions, and remained agnostic as to the identity of the co-released transmitter as we initiated and carried out the present study.
Another qualitative study will be conducted after correction of the critical points that emerged during this initial study, in a larger sample of patients.
