Initial studies identify the cell and molecular biology of interstitial cells to be an important area of research.
Initial studies identified JNKs by their ability to phosphorylate the N-terminus of c-Jun, a member of the activating protein 1 (AP-1) transcription factor family [5].
Our initial studies identified that the signature cytokine of the TH-17 pathway, IL-23, was selectively produced by human DCs infected with hyphae of Aspergillus or Rhizopus, by not by DCs infected with dormant spores of opportunistic fungi or the yeast form of the pathogenic fungus Histoplasma.
Initial studies identified heterozygous mutations of the phosphatidyl choline floppase ABCB4 (MDR3) in familial (19) and sporadic (20) cases.
Cre- loxP site promiscuity is not a new observation; for example initial studies identified another loxP recombination site in the E. coli chromosome, loxB [ 22].
Besides the identification of differential expression of miRNAs, our initial studies identified three reference endogenous miRNAs (miR-103, miR-191, and miR-423-3p miR-423-3p miR-423-3p
Initial studies identified a second mutation within the EGFR, which results in the resistance of the tyrosine kinase to gefitinib, as a major cause of reduced tumor control.
Initial studies identified a highly significant 16% reduction in rCBF of the pontine tegmentum/upper medulla, and less robust reduction in the thalamus.
Initial studies identified SEMA3A (semaphoring 3A) as a novel oncogenic candidate that is regulated by EZH2-silencing, using data derived from both normal and leukemic cell lines as well as murine cells deficient in EZH2.
Initial studies identified changes in diffusion measures in the hippocampi of patients with mild cognitive impairment, which predated macroscopic volume loss, with positive predictive value for progression to AD dementia.
