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The criteria for inclusion of an individual rapid HIV assay into the National algorithm were initial sensitivity of 100% and initial specificity of ≥ 99%.
Determine, SD Bioline and Uni-Gold™assays had initial sensitivity of 100%9595% CI; 99.1 100) while the initial specificity of the Uni-Gold™ assay was 100%9595% CI; 99.6 100).
Although initial specificity of the promoters was demonstrated by virtue of gene expression profiles in primary fibroblasts (Fig. 3), we next evaluated gene expression in the most relevant context, the human liver.
On initial testing, Determine, SD Bioline and Uni-Gold™ each had sensitivity of 100%9595% CI; 99.1 100) while the initial specificity of the Uni-Gold™ assay was 100%9595% CI; 99.6 100).
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After these initial examinations, specificity of all of the products was confirmed each time by melting curve analysis via LightCycler Software 3.39 (Roche).
A study evaluating 56 emergency clinicians (attending physicians, residents and midlevel providers) after didactic training showed an initial sensitivity and specificity of 70%and89%9%, respectively.
The antibody dilution was determined after initial standardisation and specificity of the antibodies was verified by using positive controls.
Initial sensitivity and specificity of the spectrum score ∆ to detect expert classified de-escalation events was 86.3 and 96.0%, respectively.
Initial studies suggested specificity of malarial retinopathy in determining a diagnosis of CM. 4 14 However, recent studies indicating presence of malarial retinopathy in non-cerebral severe malaria indicate that this finding is not specific.
The high rate of inadequate initial antibiotic treatment may be explained by the low prevalence of necrotizing S. aureus pneumonia, the low specificity of initial clinical signs and symptoms, and the adherence to treatment guidelines for community-acquired pneumonias.
The effects of sample size (recapture percentage), initial prevalence, sensitivity and specificity of the diagnostic test, transmission rate between unvaccinated badgers, Vaccine Efficacy for Susceptibility (VES) and Vaccine Efficacy for Infectiousness (VEI), on study power were determined.
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