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Our analysis of the initial sites of disease recurrence in patients who initially responded to gefitinib revealed a relatively higher prevalence of intrapulmonary and primary lesion metastasis at the initial disease recurrence site than at other organs.
Fluorescence microscopy studies suggest that the mitochondria are not initial sites of accumulation of 3.
Equilibrium titration experiments indicate that a stable folding intermediate is present at stoichiometric concentrations of Mg2 + and suggest that there are two initial sites of Mg2 + ion association.
Oncolytic viruses (OVs) have been engineered or selected for cancer cell-specific infection however, we have found that following intravenous administration of vesicular stomatitis virus (VSV), tumor cell killing rapidly extends far beyond the initial sites of infection.
The initial sites of gross disease, including the anterior mediastinal node was included in the CTV for PMRT, and treatment planning demonstrated a clear advantage to the inclusion of proton fields in this case.
Integrins are cell-surface protein heterodimers that coordinate cellular responses to mechanochemical cues from the extracellular matrix (ECM) and stimulate the assembly of small adhesion complexes, which are the initial sites of cell-ECM adhesion.
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Risk stratification may also improve patient flow and initial site-of-care decisions (i.e., outpatient versus inpatient management).
Such markers from different physiopathological pathways may provide useful prognostic information that improves management in regard to initial site-of-care decisions (outpatient versus inpatient) and expected risks.
Risk prediction may also assist physicians in more rational decision making regarding initial site-of-care with implications for the entire hospitalization.
There are a number of well validated clinical scores which predict 30-day mortality and have shown to improve initial-site-of-care decisions [ 5- 7].
Virus initially replicates within epithelial tissue in the initial site of inoculation prior to entering associated sensory ganglia, such as the sacral ganglia.
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