Sentence examples for initial single dose from inspiring English sources

An initial single dose of aminoglycosides was commonly subsequently replaced by fluoroquinolones to limit harmful side-effects.

For instance, during the first 10 years of the US program, both uptake and efficacy with the initial single dose vaccination programme were far below 100%.

The initial single dose on Day 1 was followed by a wash-out period of 72 h to determine single-dose PK.

We suggest an initial single dose of 4 units (14) of insulin administered with the largest meal; for patients taking < 40 units/day of basal insulin, a starting dose of 3 units may be more appropriate.

A good response was bleeding that stopped following the initial single dose of 180 or 150 μg kg−1 rFVIIa; a partial response was bleeding that stopped following a second dose of 90 μg kg−1 rFVIIa; and a lack of response was characterized when bleeding symptoms persisted after administration of two doses of rFVIIa.

The SIMPLIFI Phase II trial included 302 patients who were randomized to one of three treatment arms: the daily-dose arm (200 mg for 3 to 7 days), the single-dose arm (1,200 mg once), or the infrequent-dose arm (initial single dose of 800 mg, followed by reassessment on day 5 for the need of an extra dose of 400 mg).

Initial single-dose phase I trials demonstrated that virus administration to the CF airways was safe, but provided little opportunity to assess the efficiency of vector-specific CFTR expression.

A significant in vivo antitumour effect of metronomic irinotecan was detected with both the adopted schedules; however, the administration of the initial single higher dose of irinotecan followed by the low-dose treatment confirmed to be more effective than the low-dose treatment alone.

An initial single ascending dose (SAD) study in 48 healthy human subjects (ClinicalTrials.gov Identifier NCT00847249) established the safety and tolerability of AZD9164 at lung deposited doses ranging from 4 to 1940 μg, and indicated a bronchodilating effect at the higher doses (≥700 μg).

Here, we report our experience on the use of an initial single bolus dose of rFVIIa (180 μg kg−1 in children and 150 μg kg−1 in adults) for the management of mild-to-moderate bleeding episodes in haemophilia A patients with inhibitors.

Although the initial (after a single dose) decrease in mRNA expression of the ET transporter OCTN1 in the liver, the expression levels returned to normal (same as controls) after 28 days.