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The illumination intensities were low and varied between 0.5 and 1 μW at the back focal plane of the objective lens providing just enough initial signal for an efficient optimization.
The downregulation of Pax7 by constant MyoD expression is described to be the initial signal for differentiation of the cells (Figure S5A B) [36], [37], [38], [38].
Assuming that the barbel develops by evolutionarily conserved epithelial-mesenchymal interactions, the initial signal for outgrowth is likely to come from one of a few gene families already well investigated in birds and mammals [56].
An initial signal for C10orf88 (in the vicinity of ACADSB) was not replicated.
The initial signal for sex determination in Drosophila is the number of X chromosomes (Erickson and Quintero 2007), which results in males being hemizygous for ∼20% of the genome.
Most of the known intrinsic currents that are capable of maintaining prolonged depolarization and firing require a strong initial signal for their activation (Fleidervish and Gutnick 1996; Pedroarena and Llinás 1997).
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AY107195 also associates with flowering time (POLL) and it is expressed in vegetative tissue where the initial signaling for flowering occurs [18], [19].
Future strategies may involve transcriptional autofeedback loops to amplify initial signals, for example, modifying L. lactis to express additional cCF10 in the presence of enterococcus-produced cCF10.
The compensatory growth of liver after hepatectomy of the ventral lobe occurs in zebrafish and this process, similar to those in rodents and humans, is closely associated with the activation and proliferation of hepatocytes [ 6], but origins of the initial signals for the activation of hepatocytic cells in the remaining liver lobes are largely unknown.
Overexpression of this protein inhibits the initial signal responsible for its own induction by blocking the Jak/STAT pathway.
Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine).
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