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Following initial sensitization with HDM on D0, animals were dosed daily with MRx0004 from D7 until D17.
Some of these inconsistencies may be due to abnormal initial sensitization effects to startle-eliciting stimuli.
A weak stimulus, or one with little intrinsic biological significance, will show relatively rapid habituation and little or no initial sensitization.
In patients who developed MOH the cortical response pattern could be locked in a pre-ictal state associating both initial sensitization and late deficient habituation, which contrasts with episodic migraine where these cortical states alternate (Figure 1).
Serum samples were taken 3 months after initial sensitization of mice.
At seven weeks from the initial sensitization, the pigs were challenged via intradermal and intratracheal administration of the allergen.
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These facts suggest that extended airway remodeling induced by GO exposure contributes to the enhanced AHR in GO-treated mice sensitized to OVA. Surprisingly, GO exposure upon initial OVA sensitization suppressed Th2-driven responses.
In conclusion, we show for the first time that not only is the response pattern of the somatosensory cortex in CM patients similar to that found during a migraine attack in episodic migraine patients, in such a way that both habituate normally, as previously observed with visual responses [52], but also that they show an initial response sensitization.
We found that all animals developed strong skin hypersensitivity reactions in the painted back skin after ≥8 days of initial DNCB sensitization (Figure 1B).
Various subtypes of DNCB-specific Abs, including IgG, IgG1, IgG2a, IgG2b and IgA (but not IgE), were detected in the serum of these animals at ≥8 days following the initial DNCB sensitization(s) (Figure 2D and Figure S3).
Importantly, the initial peripheral sensitization by capsaicin was unaffected (Jimenez-Diaz et al., 2008).
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