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The sharp initial risk increase is likely because of trial consent (excluding moribund patients); the earliest deaths occurred on day 8 (DART) and day 16 (ARROW).
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In the SIM protocol, DFS was statistically higher for TN than for non-TN patients (P=0.019), although we showed that the TN status was associated with an increased initial risk of recurrence in both regimens.
Overall, TN status was associated with an increased initial risk of recurrence that gradually decreased (P=0.004) as well as a hazard ratio (HR) of 2.33 (95% CI (1.21 4.49)) during the first 24 months of follow-up until 0.16 (95% CI (0.02 1.21)) after 48 months of follow-up.
Sclerotherapy could increase the initial risk of (variceal) bleeding but have a protective effect over time, eventually translating into an overall treatment benefit.
"The risk increase is not insignificant".
Lupus doubles the normal risk (increase 100%).
However, Ruths et al. found that only loop diuretics were associated with an initial increased risk of hip fractures during the first 2 weeks of use when comparing the initial fracture risk among antihypertensive class (Ruths et al. 2015).
Few studies have examined the initial increased risk of fractures associated with starting antihypertensive therapy, and how the association between antihypertensives and fractures varies time.
Stillbirth risk increased with each event.
The risk increased with greater exposure.
The risk increases exponentially.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com