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Although further analysis may cause us to reject our initial recognition, that recognition is, when appreciative, more dependable than analysis.
As is so often the case with human beings, for our minds seemed geared to create dichotomies, Simpson's categories were foreshadowed by Darwin's and Cuènot's initial recognition that preadaptations originated in two different ways: (1) a neutral or deleterious trait acquiring an adaptive function in a new environment and (2) a useful (adaptive) trait changing function.
After the initial recognition that the Times Square attempt was amateurish and the police and intelligence work exemplary, politicians are now suggesting that we were simply lucky and the hapless perpetrator is actually too dangerous to be handled in our criminal justice system.
The application of 16S rRNA and dnaG gene sequencing led to the initial recognition that the organism was in fact composed of several species, and formed a unique genus that was distinguishable from Enterobacter [ 14].
More than 25 years after the initial recognition that HIV can directly damage the central nervous system (CNS) and lead to dementia [ 1], HIV-associated neurocognitive disorder (HAND) now encompasses a transformed spectrum of conditions due to the relative immune recovery or immune preservation facilitated by dramatic advances in antiretroviral therapy (ART).
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The initial recognition events that precede uptake may involve several molecules, proteins [ 16] and lipids [ 12] have already been indicated as involved in this process.
From the initial recognition in 1988 that research was needed, to agreement that a randomised controlled trial was the appropriate design, took the UK MRC and Departments of Health two years.
These molecules mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together to destabilise the lipid/water interface and to initiate the intricate mixing of the lipids merging the two lipid bilayers to become one [ 14].
But the historic focus of climate diplomacy on caps and cuts may slow down progress on the pathway that really offers the greatest initial promise -- a recognition that rapidly lowering the carbon intensity of every nation's economy, while making low carbon economies more dynamic and robust, is the most promising pathway to a critical mass of ambitious climate commitments in Paris.
In the context of Nod2 SNPs, the data presented would support the hypothesis that initial recognition and potential lysis of the intracellular bacteria by Nod2 is deficient in genetically defined patient populations.
The pre-eminence of TLRs and these associated signalling molecules in the initial recognition of pathogens suggests that they could be strong candidates for animal health traits.
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