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The initial rationales for this study were that fulvestrant 500 mg might be biologically more potent than an AI and also that a synergistic effect of combining the two could be achieved.
One of the initial rationales for the development of anti-angiogenic therapies in general, and metronomic chemotherapy in particular, was based on the idea that, unlike cancer cells, vascular endothelial cells are genetically stable and thus less likely to acquire drug resistance [ 1, 11, 12].
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They recall that the initial rationale for aiding Contras with money was more circumscribed.
Absent by design from this message is the administration's initial rationale for the war: to protect the United States from weapons of mass destruction.
The initial rationale for this was a bit mysterious, but it's now fairly clear that it was part-and-parcel of the drive toward war in Iraq, which required that military resources not be unduly tied down fighting al-Qaida and stabilising Afghanistan.
The initial rationale for implementing QRIS is to enhance the quality of accessible care.
The initial rationale for use of organic nitrates and hydralazine (HYD) in combination was their complementary "nitroprussidelike" hemodynamic effect caused by the predominant venodilatory action of organic nitrates and the arterial-dilatory effect of HYD.
As a class, the acyclic nucleotides have long intracellular half-lives, allowing once-daily dosing, which provided the initial rationale for treatment of chronic viral diseases such as HIV and HBV.
The initial rationale for the firing was laid out in a letter written by Deputy Attorney General Rod Rosenstein that criticized Comey's handling of the investigation into Clinton's emails.
The initial rationale for using pentoxifylline was due to its ability to inhibit TNF-α transcription.
However, this finding does support our initial rationale for collecting multiple data points for individual groups of students, as their discussions are different on the different topics.
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