Exact(27)
Although these cells may help in the containment of the bacilli during the initial phase of infection, their involvement in TB pathogenesis is supported by a number of studies.
During the initial phase of infection mice immunized with rBCG-NS inhibited growth of virulent Mtb robustly.
Results suggest that CD4+ cells are the major contributors to IL-17A production in infected LVS lungs, yet γδ T cells may have a role in the initial phase of infection (Figure 6D).
No difference was observed between the two mouse strains during the initial phase of infection but from 24 h up to 40 h post-infection the parasite burden in BALB/c mice was significantly lower (Figure 1).
Expression of the chemokines genes (Ccl-2, >200-fold; csf2, >10-fold and Ccxl-10, ∼30-fold) and surface receptor molecules (FasL, >2.5 fold and IL-2R, 4-fold) were upregulated at the initial phase of infection, but decreased at later time points (Fig 10b, c).
This initial phase of infection, until the systemic viral dissemination begins, constitutes the eclipse phase [ 1].
Similar(33)
Analysis of the larval worm transcriptome (Parkinson J, Maizels RM, Fernández C, unpublished) revealed the existence of a multigene family of Kunitz inhibitors expressed mostly in pepsin/H+-treated protoscoleces, suggesting that these molecules play a role at the initial phases of infection.
Furthermore, about half of these HPV seropositive women produce neutralizing antibodies capable of preventing initial phases of infection [ 8].
Changes of the mouse hepatic gene expression in response to primary hepatic E. multilocularis infection were examined during the initial phase of chronic infection stage (i.e. after 1 month).
Moreover, G-CSF may work in the initial phase of RSV infection, such as within 8 hours after infection.
It is assumed that initial signals emanate from those few mucosal cells which become infected in the initial phase of the infection, and that these initial signals are amplified subsequently in order to mount a tissue-wide defense.
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