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Recent genetic studies have excluded that peripheral innervation plays a substantial role in the initial outgrowth of the olfactory bulb.
The initial outgrowth from myocardial samples was enriched for sub-populations of CPCs (c-Kit+), endothelial cells (CD31+, CD34+), and mesenchymal cells (CD90+).
Therefore we selected MF-start™ that was developed to readily obtain initial outgrowth of cells with low proliferating activity at primary culture.
In conclusion, our goal was to succinctly capture the salient features of the empirically-measured initial outgrowth distributions in a simple model with a minimal number of parameters.
However, after this initial outgrowth of the jp edge, it later shows bands (revealed by birefringence in young adult fish, data not shown).
Wnt signaling has been implicated in the regulation of early patterning and initial outgrowth of the vertebrate limb bud [1] [4].
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Subsequent serial transplantation and regeneration of the initial outgrowths demonstrated the existence of the self-renewing population.
Alternatively, the specificity of axonal branching might be the result of initial excessive outgrowth and exuberant branch formation during development followed by a refinement process to eliminate the majority of branches, as in refinement observed in mammalian visual map formation (Feldheim and O'Leary, 2010), for example.
As shown in sh-K cells, shortly after the initiation of differentiation process (6 8 days) and preceding the initial neurite outgrowth, ruffling on the cell surface, which is primarily due to disruption of the subcortical actin network (F-actin), was observed.
For simplicity, we only differentiated between initial neurite outgrowth in the developing embryo and dendrite maturation, which includes morphological changes during later outgrowth, branching, guidance, and pruning.
The loss of GABAergic synapses in ju89 young adult worms thus appears more severe than can be accounted for solely by defects in initial axon outgrowth, suggesting that ju89 may disrupt synapse formation and function independently of an earlier role in neuron outgrowth or guidance.
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