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Figure 3 summarizes the results of the initial meta-analysis with all etiologies of CP combined.
These results were similar to those of the initial meta-analysis in which all the studies were included.
An initial meta-analysis was performed using all studies.
A repeat of the initial meta-analyses with fixed effects models confirmed the primary meta-analysis.
The initial meta-analysis was prespecified in collaboration with the Cochrane Database of Systematic Reviews [ 16].
Initial meta-analysis results pointed to an excess of associations compared with the null distribution (Fig. 1A).
The initial meta-analysis found the intronic single nucleotide polymorphism (SNP) rs1935062 the most promising marker (p = 0.0019) [ 4].
Two more studies were thus added to our initial meta-analysis and the results are shown in Figure 1.
Initial meta-analyses used a fixed effect model [ 43] to provide an overall pooled measure of effect.
QQ plots of our initial meta-analysis results showed high deviation from the null, yet, after QC we observe no inflation of signal.
However, this is the first and initial meta-analysis of assessment whether TS expression is associated with objective response in patients with NSCLC treated with pemetrexed-containing chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com