Another improvement that does not require arbitrary restrictions of the huge initial identifier space was proposed in [11].
The algorithm starts with a set of initial atom identifiers for each atom and iteratively updates those identifiers similar to the Morgan algorithm [ 49].
In each iteration the circular substructures are extended at their possible attachment points using the initial atom identifiers (Figure 1).
We explicitly model the growing substructure by using the initial atom identifiers in each iteration and keeping the connectivity information between the layers.
The algorithm starts with the initial atom identifier (in our case Daylight invariants [17]) of the center atom and grows a circular substructure around this atom.
The algorithm starts with the initial atom identifier of the center atom and grows a circular substructure around this atom throughout a defined number of iterations (search depth).
We used 36,396 Ensembl Gene IDs as the initial set of identifiers for H. sapiens genes, which was further reduced to 21,341 genes as described in the section Predictive features.
(The ID here is MIH Identifier. EAP uses this identifier in it's initial messages for identifying itself with the peer).
The largest CNV call was assigned the initial CNV locus identifier.
All principal investigators were contacted in order to provide individual patient data, which were transferred without patient identifiers (initials and birthday) to the Eastern Piedmont University, Novara, Italy.
