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We began by examining the locomotor data from the initial habituation session in order to determine whether any differences in response to novelty existed.
An unpredictable 180-s variable-interval schedule was in effect for 90 min on the correct lever (signaled by a constantly lit cue light above this lever) from session 13 (calculated from the initial habituation session) until the study was finished.
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> -wrap-foot> > -wrap-foot> There were no significant differences in activity due to genotype or AMPH sensitization status during an initial 60 min habituation session [ F 1,27) = 0.00, n.s. and F 1,27) = 1.79, n.s., respectively] or during the 60 min after vehicle injection [ F 1,27) = 0.48, n.s. and F 1,27) = 0.33, n.s., respectively].
One day after the habituation session, spatial working memory training begins.
Sleep EEG recordings were performed on days 6 and 7 after an habituation session.
The first followed a 24-h habituation session to the recording chamber (baseline).
After 3 days of recovery, mice were head-restrained with the headplate fixed to a metal bar for 1 h habituation session.
Firstly, all animals were submitted to a habituation session, freely exploring the object free open field for 5 min.
The challenge with cocaine, preceded by another habituation session, was done on the fourth day.
After a habituation session animals were placed for 10 min into the box with two identical objects.
Socially housed controls were placed as a group into a clean home cage 24 h before their habituation session.
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