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Initial filtering of obtained sequences was performed using quality information.
Our initial filtering of the two VCF files resulted in a compendium of 2,094,954 sites.
The exemplary result of initial filtering of the skin lesions is presented in Fig. 3.
Given the global Katz centrality, users were required to provide the desired centrality for initial filtering of the nodes.
This information will be used to conduct an initial filtering of candidate InPs and provide the resulting list as input to the selection and binding processes.
We have shown here that, compared to simply ranking the poses output by the docking program according to a single docking score, an initial filtering of the docked poses with a pharmacophore query to remove poses that do not form certain essential interactions with the target binding site greatly improves the quality of the results.
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The model also predicts a general weakening of this initial signal with increasing numbers of inter-chromosomal re-arrangements, as the hypothesis proposes only an initial filter of block duplications, not ongoing direct selection to maintain linkage.
Preliminary analysis indicated phenotype outlier effects causing spurious significant findings due to the lower MAF threshold; after applying an initial filter of association p < 5 × 10 8, we recomputed the chemical × SNP analyses after applying an inverse quantile normalization to EC10.
In such an application the goal is to perform an initial filtering to reduce the amount of files to investigate manually.
However, initial filtering value of EKF can only be obtained bysolving over-determined nonlinear equations, which can never be avoided.
The initial filtering criteria of p < 0.05 for sex or age difference with an absolute fold-change greater than or equal to 1.5 in relative expression at any age was used to define a set of 7,951 differentially expressed features comprising 3,770 unique Entrez Gene IDs or differentially expressed genes (DEGs).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com