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This finding is crucial for the subsequent evaluation of other aspects of the overall virulence, because the ID50 value is the best reflection for the ability of a pathogen to evade the initial elimination by the first line of host defense.
These similarities can be used to explain why the two virulence factors can be interchangeable in the protection of B. burgdorferi against initial elimination by immune defenses when produced at an increased level; however, they indeed contribute differently to dissemination and tissue colonization.
However, these studies did not examine the initial elimination of TCDD immediately after high-level exposures.
In particular, it is a powerful antiplasmin agent, and the initial elimination of aprotinin is 1.5 to 2 hours [ 183].
The initial elimination half-life in normal dogs has been reported to range from 37−73h after multiple oral dosing [ 96].
Regressions demonstrate a strong BPA decline in the 4.5 8.5 hr interval, possibly representing an initial elimination phase subsequent to oral intake.
Similar(41)
The curcumin concentration decrease from the plasma appeared for the pulmonary administration to be in two distinct phases with an initial rapid elimination occurring in the first hour followed by a slower elimination from 1 to 8 h.
Donors had been slow to respond to the initial cholera elimination campaign, Ban told the Miami Herald newspaper, adding that the UN had struggled to raise an initial $400m needed in the first two years.
The initial radical elimination activity of WD-3 seed was 93.0%, which was much higher than the 56.6% of Hopum.
This weak absorptivity does not facilitate the adequate sensitivity for determination of LND levels in plasma without pre-concentration of the samples, particularly at the initial and elimination pharmacokinetic phases.
This ability is best reflected by the ID50 value because this criterion measures the smallest number of organisms that is sufficient to escape initial innate elimination and establish an infection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com