Exact(7)
Initial dispensing of 100 μl medium (MHB) in all the wells, followed by the addition of 100 μl, 90 μl and 80 μl of MHB in columns 2, 3 and 4 respectively.
Our findings on the initial dispensing of GERD treatments suggested that prescribing in hospitals, especially dispensing in in-house pharmacies adversely affected the use of generic drugs.
First-line therapy with nab-paclitaxel was defined as initial dispensing of nab-paclitaxel as the first chemotherapy received after a diagnosis of metastatic disease.
The baseline period was defined as the 6-month interval prior to the initial dispensing of one of the study drugs.
Patients eligible for the study were 18 to 74 years old at the time of the initial dispensing of PPIs or H2RAs for the treatment of GERD in an outpatient setting.
All liquid handling after the initial dispensing of lysis buffer to the tissue samples was performed using a 96-tip MCA pipetting head with tip washes between each process step.
Similar(53)
Of the measures we studied, those that required an initial dispensing for their calculation, particularly if not bounded above by 1 (i.e., CMA1-2), were prone to exhibit an upward bias relative to the other measures we considered.
At the initial dispensing, 81.8% of patients received branded drugs, and 79.4% of patients received PPIs.
The percentage of patients who received generic drugs once or multiple times from the initial dispensing increased over time, whereas the percentage of patients who switched from branded to generic drugs remained very small.
CMA7 and CMA8 do not exhibit any evidence of a time bias, presumably since they don't require an initial dispensing (and its attendant implied adherence) to trigger the calculation.
A total of 14,590 patients (male: 50.2%) were included, and mean (±SD) age at the initial dispensing was 43.1 (±12.2) years.
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