Initial dispensing of 100 μl medium (MHB) in all the wells, followed by the addition of 100 μl, 90 μl and 80 μl of MHB in columns 2, 3 and 4 respectively.
At the initial dispensing, 81.8% of patients received branded drugs, and 79.4% of patients received PPIs.
Multivariate logistic regression was performed to investigate factors associated with receiving generic drugs using data at the initial dispensing.
A total of 14,590 patients (male: 50.2%) were included, and mean (±SD) age at the initial dispensing was 43.1 (±12.2) years.
Our findings on the initial dispensing of GERD treatments suggested that prescribing in hospitals, especially dispensing in in-house pharmacies adversely affected the use of generic drugs.
First-line therapy with nab-paclitaxel was defined as initial dispensing of nab-paclitaxel as the first chemotherapy received after a diagnosis of metastatic disease.
The baseline period was defined as the 6-month interval prior to the initial dispensing of one of the study drugs.
Of the measures we studied, those that required an initial dispensing for their calculation, particularly if not bounded above by 1 (i.e., CMA1-2), were prone to exhibit an upward bias relative to the other measures we considered.
At the initial dispensing, patients who received branded drugs (patterns 1, 3, 5, and 7) were more likely to receive PPIs than those who received generic drugs (compared with patterns 2, 4, 6, and 8, respectively).
All liquid handling after the initial dispensing of lysis buffer to the tissue samples was performed using a 96-tip MCA pipetting head with tip washes between each process step.
