Your English writing platform
Discover LudwigExact(1)
Baseline variables included age, sex, race, disease severity, a calculated index of rate of initial cognitive decline from symptom onset to cohort entry (pre-progression rate or PPR), years of education, and medical comorbidities (diabetes, hypertension, hyperlipidemia, coronary disease, cerebrovascular disease).
Similar(59)
The average duration from initial symptoms to cognitive decline is 32.5 months, ranging from 22 to 48 months.
A longitudinal study found that psychosis in AD (observed in 7.8% of patients) was associated with greater initial cognitive dysfunction, more accelerated cognitive decline, and greater mortality [ 97].
Based on amyloid cascade hypothesis, elevated levels of A β have been correlated with cognitive decline, mediating initial pathogenic events in AD dementia [ 3, 4] such as the accumulation of senile plaques and plaque-associated dystrophic neurites in the brain [ 5, 6].
Informants also reported on participants' years since onset of cognitive decline at the initial NACC-UDS visit.
The most important predictor of mortality was a faster rate of cognitive decline at the initial patient visit (PPR).
The aggregate decomposition results (either at means or along the distribution) additionally suggest a decreasing role of the characteristic effect in contributing to the total gap as students advance to higher grades.19 This is consistent with the declining contribution of initial cognitive skill endowments to the total characteristic effect as students progress through school.20.20
The former finding is in contrast with some but not all previous analyses where education has been linked to initial cognitive level but not the rate of decline [ 12, 29, 30].
This may account for much of the apparent cognitive decline in people with high initial scores on the MMSE.
This might indicate that our initial model had missed the small differences in cognitive decline between incident diabetic patients and control subjects.
Early Alzheimer's disease itself might lead to lower physical activity, but the researchers eliminated that possible explanation because the initial level of activity was not associated with previous cognitive decline.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com