In LOAD, accumulation of toxic Aβ and p-tau may not be the initial cause of neural degeneration and may instead be consequences of other causative factors5,6.
However, there is increasing evidence that in LOAD the accumulation of these toxic molecules may not be the sole or initial cause of the disease and may instead be consequences of other causative factors4,5,6,9,10.
No initial cause was given.
But the initial cause of the protests was economic.
The initial cause of the protests were austerity measures, such as increased food and fuel prices.
The initial cause was the police shooting of a teenage boy.
One was a merchant, the other a banker; and the initial cause of dispute was a refusal of credit.
He said they told him they believed that "the initial cause of the accident is the destruction of the internal forward tire of the main left wheel carriage".
The volcano's eruption – an initial cause of wonder that turned quickly into terror and tragedy – is recorded in a single surviving eyewitness account by Pliny the Younger.
Ken Saro-Wiwa's initial cause, for example, was the devastation that Royal Dutch/ Shell's oil spills inflicted on Ogoni land in Nigeria's delta region.
Whatever the initial cause, however, the current guess is that a local event turned into an epic blackout because the transmission network has been neglected.
