We then chose parameters in which our models exhibited similar initial and final f-I curves to those of the experimental pyramidal cells.
We determined the rheobase current and the slope of the initial and final f-I curve over 10 Hz (using a least squares approach) for each model in order to settle upon a final model in which our initial and final f-I slopes and rheobase approximated that which we determined biologically.
As with the experimental frequency-current (f-I) curve frequencies, we exhibited the "initial" and "final" f-I curves for each model, where the initial curves were based on the inverse of the first inter-spike interval (ISI) due to a one second current step, and the final curves were based on the inverse of the last ISI.
We then varied the parameters a, b, d, and k low to produce multiple models, and again determined the rheobase current and the slope of the initial and final f-I curve over 10 Hz (using a least squares approach) for each model.
Nonzero matrix elements of σ̂ z physically reflect expansion of the solvent polarization around the minima of the electronic diabatic surfaces corresponding to the initial (I) and final (F) electronic states.
At study completion, percentage tumor growth inhibition (%TGI) values were calculated for each treatment group (T) versus control (C) using initial (i) and final (f) tumor measurements according to the formula: %TGI = (1 − [ T f − T i]/[ C f − C i]) × 100.
Also, the measured initial and final dissolved F (Table 1) did not indicate any noticeable decrease in fluoride.
The (definite) integral of the function f, between initial and final values t = a and t = b, is the area of the region enclosed by the graph of f, the horizontal axis, and the vertical lines t = a and t = b, as shown in the figure.
Model 4 actually contains many models, selected by choosing a different set of explanatory variables x or restricting the initial and final probabilities P i and P f.
Relative fitness was calculated as w = ln (A f / A i ) / ln (B f / B i ), where A and B are the densities of the two competitors, and i and f represent initial and final densities, respectively.
Relative fitness was measured as: w = ln (A f / A i ) / ln (B f / B i ), where A and B are the densities of the two competitors and i and f represent initial and final densities, respectively.
