Sentence examples for initial activating from inspiring English sources

Given the high concentrations of CaMKII in synapses and the fact that calmodulin is limiting (Liu and Storm, 1990; MacNicol and Schulman, 1992; Persechini and Stemmer, 2002), subunit exchange provides a potential mechanism for increasing the spread of activation caused by an initial activating pulse.

In coping with stress, EIF2AK4 decreases global protein synthesis, increasing specific mRNA synthesis for transcription factors and enabling cells to initiate a survival response to the initial activating cue.

Rather, the optimal distance depends on the specific shape of the spatial pattern of the initial activating ligand and the noise pattern of the primary response.

The TKDs in Figure 2(A) resemble IRK, with the initial activating event likely to be autophosphorylation of the tyrosine side chain projecting into the substrate-binding site (Tyr in TrkA, Tyr in Ror2, Tyr in IRK, Tyr in IGF1R and Tyr in MuSK), thus reversing autoinhibition [ 13, 15].

Assay conditions for the real-time PCR were adjusted using an optimised PCR protocol with the following profile: initial activating of Taq-polymerase at 95°C for 15 minutes, followed by 35 cycles with denaturation at 95°C for 15 seconds, annealing at 60°C for 15 seconds, and extension at 72°C for 20 seconds.

Once the automatic ventilation is started, the initialization activates all initial settings of ventilation variables, such as PEEP, FiO2, VT, RR, and I E ratio.

We report the identification of 4-aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of EGFR, with excellent activity against the T790M resistance double mutants and initial single activating mutants.

Real time PCR was performed in triplicate on a MX3000P Stratagene (Cedar Creek, TX, USA) instrument running an initial enzyme activating step of 95°C for 10 min, followed by 45 cycles of denaturation at 95°C for 30 sec, annealing at 60°C for 30 sec, and extension at 72°C for 30 sec.

APOBEC3B could have been responsible for the initial kinase activating mutation, as well as additional genetic changes that occur in descendent cells, including therapy resistance mutations, especially if they confer a selective advantage.

These results suggest that the expression of EBNA-2 at the initial stage activates the CD23 expression which continued to increase up to 72 hrs.

This is consistent with a mechanism whereby the initial depolarization activates VGCCs that finally change the frequency of intracellular calcium oscillations (Bortone and Polleux, 2009).