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The level set method introduces an implicit representation of a singular surface where it transforms into a thin transition layer of non-zero thickness where all quantities take inhomogeneous expressions within the body.
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However, the cell pools displayed an inhomogeneous expression pattern at non-saturating levels of 0.1 2.0 µg/mL: while cells from the 'low' population provided a bimodal distribution, the 'high' population cells remained fully induced at inducer levels of 0.5 µg/mL and above (Fig. 5A).
Inhomogeneous expression of iNOS interferes with regional blood flow and promotes shunting from vulnerable weak microcirculatory units [ 23].
We observed a weak and inhomogeneous expression of CD73 in the cytoplasm and cell membrane, which was more pronounced in the basal layer in 4 out of 6 cases (Supplementary Figures S1A C, F).
It is experimentally proven that the same signaling pathway can be activated differentially in different tissues or cell lines and thus can exhibit tissue-specific inhomogeneous expression patterns of the target genes or proteins (70, 71).
An important aspect of this approach is its ability to generate cytotoxic metabolites that diffuse locally to cause a bystander effect, thereby compensating in part for spatially inhomogeneous transgene expression.
While the mutant alone showed homogeneous expression in the ER, the expression pattern became inhomogeneous after co-expression with Ostm1.
Clinical mucin staining often fails to identify mucins, either because of dilution, low level of expression, inhomogeneous distribution within the fluid sample or interference by other glycoproteins.
We had indeed noticed the apparent inhomogeneous pattern of TRPC3 expression in the Allen Brain Atlas and we now refer to it in the Discussion.
It is possible that not all the cells respond similarly to Eve or Ftz it is known that the initial en expression is inhomogeneous (DiNardo et al., 1985).
This threshold was set in order to avoid underestimation of VDR expression in lymphoma cases with inhomogeneous staining due to possible fixation artifacts of the tissue.
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