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Indeed, MEK inhibition on normal stem cells (induced pluripotent stem cells and embryonic stem cells) maintains self-replication of the pluripotent state and inhibits their commitment to differentiate.
Similar(59)
Pluripotency factors might as well function as classical lineage specifiers that direct ESCs to differentiate into a specific lineage and inhibit their commitment to mutually exclusive lineages [14].
Thus, HDAC inhibition keeps progenitor cells in a more primitive state and inhibits their commitment towards DC lineage.
Testosterone regulates lineage determination in mesenchymal pluripotent cells by promoting their commitment to the myogenic lineage and inhibiting their differentiation into the adipogenic lineage through an androgen receptor-mediated pathway.
Their commitment to nonviolence was complete.
"Countries renewed their commitment to reforms.
Their commitment to community welfare helps to reinforce precious stability.
But what about their commitment to covering the news?
Meanwhile, they repeat their commitment to the dollar peg.
"It has to do with their work ethic and their commitment to their art".
They will make their cases on their electability and their commitment to conservative principles.
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