It inhibits the function of VEGF165 and functions as a MRI contrast agent.
This study was designed to examine whether gefitinib inhibits the function of Pgp.
For example, Clioquinol inhibits the function of the proteasome and displays preclinical efficacy in the treatment of malignancy.
The bacteriophage P4 capsid-decoration protein, Psu, interacts specifically with and inhibits the function of Escherichia coli Rho.
GG918, a selective MDR modulator of Pgp and BCRP, inhibits the function of these transporters and increases 99mTc MIBI cellular accumulation [10].
Au(FeCo) inhibits the function of pro-angiogenic VEGF165 and hence inhibits VEGF165-induced proliferation of HUVECs and inhibits VEGFR2 phosphorylation.
It contains an iron cobalt (FeCo) core that demonstrates magnetic resonance imaging (MRI) contrast property and a thin nanoshell of gold that inhibits the function of a pro-angiogenic growth factor, VEGF165.
MDM2 hyperactivity, due to amplification/overexpression or mutational inactivation of the ARF locus, inhibits the function of wild-type p53 and can lead to the development of a wide variety of cancers.
The NS1 protein also binds and inhibits the function of two cellular proteins that are required for the modification of the 3′ ends of cellular messenger RNAs (mRNAs) (6).
IRF-7C inhibits the function of IRF-7 in transcriptional regulation of IFN genes.
The accessory protein Nef interacts with and inhibits the function of the cellular proapoptotic protein, ASK1 [17].
