Sentence examples for inhibits class from inspiring English sources
Although MC1568 (Fig 1A; Mai et al, 2005) blocks the cellular activity of HDAC4 in vitro, no inhibition is seen with MS275, which inhibits class I (1, 2 and, to a lesser extent, 3), with the exception of HDAC8, or with valproic acid (VPA; Fig 1B left).
Finally, sodium butyrate, a short-chain fatty acid sodium salt, primarily inhibits class I HDACs, but also HDAC 10 [47].
Previous studies have shown that the M.tb 19-kDa lipoprotein inhibits class II major histocompatibity complex transactivator (CIITA) expression normally induced by IFN-γ treatment [20].
VPA inhibits class I/IIa HDACs at very low concentrations compared to butyrates (Mai and Altucci 2009).
In B lymphocytes, SLPI inhibits class switching by interfering with NF-κB-dependent pathways and with the upregulation of AID induced by BAFF and viral RNA.
In contrast, 3-MA inhibits class III phosphatidylinositol 3-OH kinase that is required for autophagosome formation, an early stage in autophagy [ 13].
However, the effects of PI-103 and BEZ235 are most likely not to be due to inhibition of mTOR as ZSTK474, which inhibits class-I PI3K isoforms, but not mTOR, has very similar effects.
Besides VPA (inhibits classes I and IIa HDACs, Figure 1B and reference 7), the 4 cell lines also showed differential sensitivities to MS-275 (a class I selective-HDACI) and SAHA (a pan-HDACI) [5], as determined by MTT assays (Figure 1C).
We present evidence that the HDAC inhibitor, trichostatin A (TSA) that reversibly inhibits classes I and II HDACs (Yoshida et al., 1995; Marks et al., 2001), in combination with ML-60218, synergistically arrested the growth of exocrine pancreas in zebrafish larvae by blocking cell cycle progression and up-regulating expression of the cyclin-dependent kinase (cdk) inhibitors.
Sodium butyrate was found to competitively inhibit class I HDAC and class II HDAC (Sekhavat et al. 2007).
On the contrary, BLIP does not inhibit class B, C and D β-lactamases (Strynadka et al. 1994).
