Mapping the epigenetic landscape of pairs of such cross-inhibitory "master regulators" should therefore be of particular interest in understanding both normal development and induced cell fate reprogramming, and can be greatly aided by detailed quantitative characterization of the interactions between these regulators.
We hypothesized that DNA-level disruptions affecting the master NRF2 inhibitory complex may account for this discrepancy.
These results suggest that long-distance, excitatory projections, but not local inhibitory inputs, to NAc MSNs of master mice are involved in mediating the acute response of cocaine.
Such shift in the T-cell subset balance could involve an inhibitory effect of Bcl-6, the master transcription factor of TFH cells, on the expression of Blimp-1, which contributes to the formation of other T effector subsets.
Further, expression of the brown adipose master regulator Prdm16 and its inhibitory microRNA-133 are also deregulated.
Nanog, another master factor, can bypass leukemia inhibitory factor (LIF /STAT3 to maintain ES cell self-renewal [ 4, 5], and Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonic endoderm lineage [ 5].
A subsequent genome-wide in vivo screen using T cell-specific transposon mutagenesis identified PDCD1, which encodes the inhibitory receptor programmed death-1 (PD-1), as a master gene that suppresses oncogenic T cell signalling.
TGFβ and interleukin-6 (IL-6) are required for induction of the master transcription factor RORγt, but too much TGFβ is inhibitory.
Versions of such a master equation for, e.g., one population only or coupled inhibitory and excitatory populations were considered in [3, 22], and a van Kampen systems size expansion was carried out.
The relationship between cell cycle inhibitory effect of p53 and its regulatory effects on the expression of master early differentiation transcription factors remains to be determined.
Furthermore, the chemotherapeutic potential of S. triloba was noticed through significant inhibitory activity of this plant against HIF-1α mRNA expression, which is a master transcription factor related to cell proliferation/survival and resistance to chemotherapy and radiation [ 34].
