Sentence examples for inhibitory affinity from inspiring English sources
Their inhibitory affinity, selectivities, and possible inhibition mechanisms are discussed.
A size exclusion HPLC based helical bundle formation (HBF) assay was developed to evaluate in vitro inhibitory affinity of the inhibitors.
Modifications of the linker length resulted in weakened inhibitory affinity, consistent with the geometric requirements of an enzyme-catalyzed dissociative transition state.
The larger and much more open active site architectures of 2C9 may explain the weaker inhibitory affinity of chrysin towards 2C9.
Our kinetics studies demonstrated that the nature product chrysin exhibited a high inhibitory affinity of 54 nM towards human cytochrome P450 1andand was comparable to α-naphthoflavone (49 nM), whereas it represented a moderate affinity of 5225 nM against human cytochrome P450 2C9.
A fluorescence polarization (FP) assay was used to measure the inhibitory affinities of small molecules against the MDM2-p53 complex as previously described by us (Supporting Information Table S1).
Murine neutrophils express three activating receptors: the high-affinity receptor FcγRI (CD64), the low-affinity FcγRIII (CD16), and the intermediate-affinity FcγRIV, and one inhibitory low-affinity receptor, FcγRIIb (CD32) [ 16].
FcγRIIb is an inhibitory low affinity IgG receptor expressed on many inflammatory cells, including monocytes, macrophages, dendritic cells, B cells, mast cells and basophils[15].
The saturation effect leading to inexact adaptation in this case is the consumption of the additional "inhibitory" high affinity component, and this is qualitatively similar to other saturating mechanisms leading to inexact adaptation (see the discussion in [ 35]).
Immune complex-induced coaggregation of the FcεRI with the inhibitory, low-affinity receptor for IgG, FcγRIIB (CD32), results in suppression of FcεRI-mediated MC activation [ 87].
A series of 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinolines was synthesized and these compounds were evaluated for their PNMT inhibitory potency and affinity for the α2-adrenoceptor.
