Sentence examples for inhibitor programs from inspiring English sources

In light of the strong link between LRRK2 and PD, in addition to the availability of a myriad of kinase inhibitors in chemical libraries from oncology programs, many pharmaceutical companies have LRRK2 kinase inhibitor programs.

Additionally, the lack of cross resistance with triclosan, the scaffold for other InhA inhibitor programs, is promising as it demonstrates that there are multiple ways of inhibiting the same protein without cross-resistance occurring.

PriaXplore® has been validated by a successfully out-licensed Mdm2/p53 PPI inhibitor program.

In addition, these probability values are important in predicting the possible maximum and minimum corrosion/erosion rates to efficiently design corrosion inhibitor program, which has a significant impact on project economic.

These assays have been validated through a successful TRIM24 bromodomain inhibitor program, where a micromolar lead molecule IACS-65588) was optimized using cell-based assays to yield the first single-digit nanomolar TRIM24 inhibitor IACS-95711).

Less than a year later, he was accepted into one of the first protease-inhibitor programs.

Blockade of the immune cell checkpoint inhibitors programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a powerful tool in cancer treatment, which is effective across various solid cancer types and hematologic malignancies.

One structural class of lead compounds in our cathepsin K inhibitors program is based on an arylaminoethyl amide scaffold, which has potential metabolic weak points that might be stabilized by appropriate chemical modification(s).

Several mechanisms such as transcriptional repressors, translational inhibitors, programmed translational frameshifting and translation termination, have been postulated for the control of transposition activity and minimization of its detrimental effects on the host cell [12].

These small molecules occupy distinct regions of the active site and form the basis for a rational inhibitor design program.

Once the proteomics program has determined these targets, they are then submitted for use in the in vitro enzymatic assays of our high throughput inhibitor screening program.