Sentence examples for inhibitor affinity from inspiring English sources

As an extension of the work mentioned above and complementary to sequence-based analysis of kinases, Bamborough et al. analyzed kinase bioactivity data based on inhibitor affinity fingerprints, and used this approach to rationalize cross-reactivity of compounds [21].

The approach allows prospective prediction of transporter both substrate and/or inhibitor affinity and build quantitative structure-activity relationship (QSAR) to enable early optimization of pharmacokinetics, tissue distribution and drug-drug interaction risk.

The pH dependence of the HIV-1 protease inhibitor affinity was studied by determining the interaction kinetics of a series of inhibitors at three pH values by surface plasmon resonance (SPR) biosensor analysis.

For a diverse compound set, the affinity patterns correctly classify inhibitors as having type I or type II binding modes, and we show that juxtamembrane domain docking can have dramatic negative effects on inhibitor affinity.

The crystal structures together with the analysis on the inhibitor affinity profile elucidate the roles of individual amino acid residues in the binding of ATR inhibitors, offering key insights for the binding mechanism and revealing the structure features important for the specificity of ATR inhibitors.

Such differences provide scope for design efforts with the aim to enhance inhibitor affinity in a species-specific manner.

In this system, knowledge of the fibrillation kinetics and inhibitor affinities suffices to predict the effect of kinetic inhibitors on fibrillation lag times.

The binding affinity of the peptide is comparably better than some known peptide inhibitor affinities for their own target proteins.

Because all inhibitors appear to act competitively, we interpret the measured inhibition constants (Ki) as inhibitor affinities (disassociation constants Kd).

There are four isoforms, MCTs 1 4, which are known to perform this function in mammals, each with distinct substrate and inhibitor affinities.

Permeability estimates and inhibitor affinities determined using this method match those obtained with tracer flux and patch-clamp [ 5, 7, 10, 21].