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4. Functional inhibition: The function of many proteins is the inhibition or delay of processes that lead to cell growth.
Regarding the western blotting for PI3K/Akt/mTOR signaling after p110β-specific inhibition, the function of PI3K p110β may be operated by Serine 473 Akt phosphorylation, not by Threonine 308 phosphorylation, which may be mediated by DNA-PK.
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The effect of LY411,575 on parasite development could be due to inhibition of the function of one or more of its known targets.
Inhibition of the function of MMPs is being pursued for anticancer therapy.
Inhibition of the function of this enzyme is thought to represent a novel mechanism for malaria treatment.
This suggested that CK2 inhibition restores the function of wild-type p53 independent of TNF α.
The FKBP rapamycin complex binds to the FK rapamycin binding (FRB) domain of mTOR, resulting in inhibition of the function of mTOR in the TORC1 complex.
One possible explanation for this seeming paradox might be an active inhibition of the function of Tregs in the rheumatoid joint.
Treatment options for ovarian cancer include supplementation of miRNAs that are downregulated in cancer tissue for recovery of function and inhibition of the function of upregulated miRNAs by administration of complementary nucleic acids.
This analysis introduces the potential significance of the oxidant-mediated inhibition of the function of RasGEFs on wt Ras as a regulatory outlet that prevents overactivation of wt Ras as a cause of pathophysiological responses.
We performed in vivo calcium imaging from Or22a-expressing neurons in intact antennae of Drosophila (Fig. 6A) with or without inhibition of the function of Gαo/i subunits in all the ORNs expressing the odorant receptor 22a (Or22a-GAL4).
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