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Lactate concentration remains always lower than the growth inhibiting threshold value of 150 200 mM [ 26, 27].
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However, it has been proposed that ZNM stabilizes neuronal membranes by blocking voltage-sensitive Na+ channels and also inhibiting low-threshold T-type Ca2+ channels [ 1].
The Gβγ subunit activates neuronal inwardly rectifying K+-channels and inhibits high threshold voltage-activated Ca2+ channels, leading to reduced excitability and inhibition of neurotransmitter release (Clapham and Neer, 1997).
Our data demonstrated that apelin-13 pretreatment significantly inhibited seizure threshold (p < 0.001) and tonic-clonic latency (p < 0.001) compared with the control group.
The preferential suppression of responses to suprathreshold mechanical simulation suggests that BoNT-A inhibits high-threshold mechanosensitive ion channels linked preferentially to mechanical pain.
As discussed earlier, fully transformed cells might have acquired mutations increasing cell death thresholds and inhibiting their clearance.
Furthermore, we showed that elevating c-di-GMP levels up to a certain threshold inhibited the swimming motility of B. amyloliquefaciens PG12.
The author suggested that HSP was useful only as an early warning system for sublethal Cu pollution in the ascidian, as the response was inhibited above a threshold value of the stressing agent, which was variable among species [ 77].
As we observed significant depletion of EPCs in the macaques at a dose of ATN-224 that does not affect haematologic parameters, it is unlikely that we had significant inhibition of blood cell SOD in that study, further supporting the hypothesis that doses at which red blood cell (RBC) SOD activity is inhibited exceed the threshold required for antiangiogenic activity.
On the other hand, if we consider nonuniform transmission among individuals, the epidemic threshold increases, thus inhibiting the spreading process.
We believe that there may be a certain threshold value of Tor1 activity that must be surpassed before autophagy and autophagy-related pathways are inhibited, but these thresholds may be different.
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