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Meanwhile, inhibiting the function of miRNA-21, resulting in cells growth inhibition and apoptotic cells death.
In this study, we show that the induction of Tregs by DCregs was blocked by recovery of CD40 signal via adding anti-CD40 (stimulatory) or inhibiting the function of IL-10 via adding anti-IL-10 (a functional blocker).
We have previously shown that PI3K/mTOR signaling inhibition sensitizes mesothelioma cells to drugs that are effluxed via ABCG2 transporter by inhibiting the function of ABCG2.
A drug inhibiting the function of the ABL protein has had marked success in treating chronic myeloid leukemia.
ROS damages DNA and promotes its mutation by inhibiting the function of DNA repair genes and increases the expression of DNA methyltransferases [116].
Brefeldin A (BFA) is a lactone antibiotic produced by fungal organisms which disturbs exocytosis by inhibiting the function of ADP-ribosylation factor-guanine-exchange factor.
In fact, propofol has been shown to suppress NK cell activity and increase the activity of cytotoxic T-lymphocytes, while decreasing the secretion of pro-inflammatory cytokines and inhibiting the function of cyclooxygenase-2 and prostaglandin E2 [17, 17].
Therefore, in order to design new compounds using structure based approach for inhibiting the function of DHDPS from P. aeruginosa (Ps), we have cloned, characterized biochemically and biophysically and have determined its three-dimensional structure.
Therefore, inhibiting the function of one protein might be insufficient to restore pRB levels and function.
We also tested the effect of inhibiting the function of endogenous RHO-1 in adult animals using C3 transferase.
Due to their role in promoting tumor neovascularization, inhibiting the function of VEGF and VEGFR has been the focus of a number of therapeutic approaches [1].
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