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Our results suggest that miR-203 plays a tumor-suppressing role in inhibiting selection and expansion of tumor-initiating cells early in tumor development.
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It may also be necessary to supplement the media with enough of the limiting resource to enable sufficient growth to surpass low density thresholds that inhibit selection of cross-feeding, or to use a higher density of the species that already cross-feeds.
It is likely to prove useful in future work, for sorting out the modalities of immune intervention able to mediate or inhibit selection of tumour variants.
The extent to which selection factors for medical school entry augment or inhibit the selection of students with an intended ultimate rural practice destination has to a large degree not been assessed.
Whether Bcl-2 over-expression can inhibit negative selection against endogenous superantigens is controversial.
It is because intrasexual aggression can effectively inhibit intersexual selection (Loher and Dambach 1989; Wong and Candolin 2005).
95 Meanwhile, latent membrane protein (LMP -2A, a mimic of functionaLMP -2A is expressed by EBV potentially to inhibit negative selection.
This may specifically inhibit sexual selection and the benefits gained from mating with differentiated partners in genes associated with improved immune responses [e.g. major histocompatibility (MHC) genes].
Thank you for sending your work entitled "T cell-specific expression of a Bcl-2 BH3 domain mutant transgene inhibits negative selection and causes autoimmunity" for consideration at eLife.
These results suggest that selective blocking of pro-angiogenic isoforms by inhibiting splice-site selection with SRPK1 inhibitors reduces melanoma growth.
Antisense oligonucleotides (ASO) have proven to be an effective molecular means to modulate pre-mRNA splicing, primarily by inhibiting splice site selection.
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