Exact(17)
Second, gemcitabine could alter dNTP levels such that viral replication is inhibited without inhibition of cellular proliferation.
21 In mice deficient for either c-src or the chloride-7 channel, bone resorption is inhibited without any inhibition of the rate or extent of formation.
Consequentially, tumor growth, when implanted with Ce6 GEM PU, was effectively inhibited without significant side effects.
Furthermore, we demonstrated that in the nucleus of doxorubicin-treated cells, DNA binding by NF-Y and transcriptional activity of the promoter were inhibited without either a decrease of NF-Y or an increase of the p53 tumor suppressor, which is known to inhibit DNA binding by NF-Y.
Tissue-restricted expression is a desirable property for candidate genes as therapeutic targets in cancer, since their function could be inhibited without damaging normal tissues, their promoters could be used to enhance expression of cell death-inducing proteins in tumor cells, and tumor-specific proteins could serve as targets for immunotherapy or site-specific delivery of antitumor agents.
Still, the maximum response to BKM120 was cytostatic, as cell proliferation was inhibited without net cell loss for up to 72 h.
Similar(43)
Extinction involves the formation of new memories that inhibit, without actually erasing, the original conditioning trace (Myers & Davis, 2007).
All religions assert that an authentic relationship with God or the sacred must be freely chosen; it is the result of a personal decision that can be neither forced nor inhibited from without.
Therefore the amrinone dose in our study inhibited PDE3 without serious hemodynamic changes.
(3) Bcl-2 directly inhibited IP3Rs without altering steady-state ER Ca2+ levels.
Prok2 cannulation acutely inhibited locomotion without affecting either phase or period in control mice, as previously observed in rat.
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