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Earlier we showed that immunization with BmAFII (Sephadex G-200 eluted) fraction of human lymphatic filaria Brugia malayi inhibited progression of Leishmania donovani infection in golden hamsters.
We provide evidence that STC1 sensitized the cells to ATP upstream of PLC, and that blocking endogenous STC1 using a neutralizing antibody inhibited progression of the calcium wave.
On the other hand, microinjection of oocytes with GDPβS has not only blocked propagation of 1-MA induced Ca2+ waves, but also inhibited progression of meiotic maturation (Fig. 2).
The SERMs also inhibited progression to invasive carcinoma.
Weekly intra-articular injections of BMP-7 inhibited progression of osteoarthritis.
We found that reduced mtDNA copy number decreased the growth rate and inhibited progression through the cell cycle.
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Inhibition of the mitochondrial respiratory function inhibits progression to G1 in parallel with a reduction in cellular ATP (Sweet and Singh, 1995).
Hence suppression of ER signaling leads to inhibition of CDK activity and the maintenance of Rb in a phosphorylated and active state inhibiting progression to S-phase.
The conclusion made from this trial is that sorafenib inhibits progression of disease independent of KRAS mutational status with no statistical differences when looking at either PFS or OS [31].
For example, the steric block at the 5' junction might inhibit initiation whereas the steric block downstream at the 3' junction might inhibit progression.
Abatacept has a sustained effect that inhibits progression of structural damage.
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