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The G tracts inhibit the usage of proximal 3′AG but often activate distal 3′AG, consistent with their increased association with alternative 3′SS and the dependence of the effect on their location relative to the target splice site.
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Moreover, oral delivery of large amount of immunogens easily elicits oral tolerance and is challenged by stomach acids upon ingestion, inhibiting the usage of oral vaccines (Holmgren et al., 2003; Levine, 2003).
At 10 n m, the AON360 had its maximal effect and remarkably reduced the relative amount of the F9del form as compared with the correctly spliced one (Fig. 3B; Supplementary Material, Fig. S2A, lanes 1 2), thus indicating that it effectively inhibited the usage of the cryptic 5′ss.
Therefore, the ultimate goal of the current study is to find a natural anticancer product able to inhibit the proliferation of human cancer cell lines with high selectivity index, safe usage, and effective anticancer activity.
To use cyclopamine as a tool to explore and/or inhibit the Hedgehog pathway in vivo, a substantial quantity is required, and as a practical matter cyclopamine has been effectively unavailable for usage in animals larger than mice.
Progress is hard when other economic drivers inhibit the transformation.
It can inhibit the overall quality of the game.
Located in the corpus callosum, this area of the brain seems to inhibit the others.
He adds that past success can sometimes inhibit the ability to innovate inside larger organizations.
Third, data breadlines inhibit the data team from achieving its full potential.
This socialized control can inhibit the role intuition can play.
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