At high levels, perchlorate can inhibit the function of the thyroid gland, leading to hypothyroidism in adults.
Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
Disrupting the Hsp90 Cdc37 interaction provides an alternative strategy to inhibit the function of Hsp90 for cancer therapy.
Farnesyltransferase inhibitors (FTI℉s) inhibit the function of Ras, a GTPase involved in carcinogenesis and T cell activation.
ATP-competitive analogs have been widely developed to inhibit the catalytic activity of Plk1, while PBD-binding antagonists are being developed to competitively inhibit the function of PBD.
In this process, MLN4924 can inhibit the function of E1, thus impeding PCNA NEDDylation, and NEDP1 acts as the deNEDDylase of PCNA.
This property is likely to inhibit the function of secreted bacteriostatic products such as lactoferrrin and lysozymes and also potentially antibody function.
Bac7 (1–35) has been shown to inhibit the function of 70S ribosomes to block protein synthesis (Mardirossian et al. 2014).
They treated Arabidopsis seedlings with chemicals that inhibit the function of HSP90 genes and produced a stunning array of developmental changes.
The results suggested that VKJP1 and VKJP3, specifically inhibit the function of ABCG2 through direct interaction with its substrate binding site(s).
Nerve agents are organophosphates which inhibit the function of the acetylcholinesterase (AChE) enzyme in the hydrolysis of neurotransmitter acetylcholine (ACh) in the human nervous system.
