Its thesis is that the designs of buildings and communities inhibit physical activity and social interactions and promote sedentary lifestyles and environmental pollution or degradation.
In a protein co-immunoprecipitation assay, we further validated that human PGRN588 593 peptide, NTS and mouse Pgrn584 589 peptide can each inhibit the physical interaction between full-length PGRN and SORT1 (Supplementary Material, Fig. S3).
To further confirm this model, we examined whether the HCV core protein inhibits the physical interaction between IPS-1 and DDX3.
Nutlin-3 inhibits the physical interaction between p53 and its inhibitor MDM2, and activates p53 responses in p53 wild-type cancer cells.
Activation of p53 in tumour cells by inhibiting its physical interaction with MDM2 has been in the focus of cancer drug discovery.
cIAP-2 could bind caspase-3 and mark it for proteasomal degradation rather than inhibit it by physical interaction [ 47].
Lethe is uniquely induced by the inflammatory cytokines TNF-α and IL-1β, and Lethe inhibits NF-κB by physical interaction to inhibit RelA binding to DNA.
Okumura, K., Zhao, M., Depinho, R. A., Furnari, F. B. & Cavenee, W. K. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.
In B. subtilis GlnR is activated in the presence of FBI-GS [ 8] and TnrA is inhibited through a physical interaction with FBI-GS [ 2, 9].
Notably, an additional mechanism regulating Nrf2 activity has been identified in breast cancer cells, where Nrf2 transcriptional activity is inhibited by the physical interaction with RAR α in the presence of ATRA (Wang et al, 2007, 2013).
Polo-like kinase 1 (Plk1) is known to inhibit p53 function by physical interaction [ 15], while phosphorylation of p53 at Ser 20 by Plk3 serves to functionally link DNA damage with increased p53 activity [ 16].
